Björn Brembs

So this is essentially what happened instead of us sitting down and thinking how we could spend our money in the most technologically savvy way to the benefit of science, scholars and society. A generation later, roughly US$300 billion poorer and none the wiser, it seems.

The ultimate Open Access timeline

tl;dr: So far, I can’t see any principal difference between our three kinds of intellectual output: software, data and texts.   I admit I’m somewhat surprised that there appears to be a need to write this post in 2014. After all, this is not really the dawn of the digital age any more.

What is the difference between text, data and code?

Lately, there has been some public dreaming going on about how one could just switch to open access publishing by converting subscription funds to author processing charges (APCs) and we’d have universal open access and the whole world would rejoice. Given that current average APCs have been found to be somewhat lower than current subscription costs (approx.

What happens to publishers that don’t maximize their profit?

Trial and error is a successful problem-solving strategy not only in humans but throughout evolution. How do nervous systems generate novel, creative trials and how are errors incorporated into already existing experiences in order to improve future trials?

Come and do research with us!

While the first day (day 2, day 3) was dominated by philosophy, mathematics and other abstract discussions of chance, this day of our symposium started with a distinct biological focus.

 Martin Heisenberg, Chance in brain and behavior

First speaker for this second day on the symposium on the role of chance in the living world was my thesis supervisor and mentor, Martin Heisenberg.

Chance in animate nature, day 2

While our own manuscript on journal rank is almost through the peer-review process, this morning I received several messages announcing the DORA (

 San Francisco declaration on research Assessment

), which I signed immediately.

Official call for an end to journal rank

*During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away.

Flashback: Programming Free Will – creative robots

For 14 years, the main research funding agency in Germany, the German Research Foundation (DFG) has stated in its guidelines that submitted grant proposals will be assessed primarily on the basis of their

 content

, rather than counting the applicants’ previous publications. However, not all of DFG’s panels seem to be on board.

Research assessment: new panels, new luck?

Notwithstanding the barrage of criticisms and warnings from every corner of the scholarly community, various initiatives, mainly in the Netherlands, Finland, Germany, France and the UK, continue their efforts for a smooth transition from subscriptions to open access without any further disruptions.

Why open access Big Deals are worse than subscriptions

When I finished my PhD 15 years ago, the neurosciences defined the main function of brains in terms of processing input to compute output: “brain function is ultimately best understood in terms of input/output transformations and how they are produced” wrote Mike Mauk in 2000 (DOI: 10.1038/76606). Since then, a lot of things have been discovered that make this stimulus-response concept untenable and potentially based largely on laboratory

Watching a paradigm shift in neuroscience

Over the weekend, I received the following short message from a Hotmail account:  This email is full of signs that the student may not have been all that interested in any information or discourse, but instead trying to make some sort of ‘gotcha’ statement. Curiously, the author first states that their scientific training is lacking and then they disagree with a scientific position.

How not to contact faculty as student

With the start of the new year 2017, about 60 universities and other research institutions in Germany are set to lose subscription access to one of the main STEM publishers, Elsevier. The reason being negotiations of the DEAL consortium (600 institutions in total) with the publisher.

So your institute went cold turkey on publisher X. What now?

In what area of scholarship are repeated replications of always the same experiment every time published and then received with surprise, only to immediately be completely ignored until the next study? Point in case from an area that ought to be relevant to almost every single scientist on the planet: research evaluation.

How scientific are scientists, really?

This is a post written jointly by Nelson Lau from Brandeis and me, Björn Brembs. In contrast to Nelson’s guest post, which focused on the open data aspect of our collaboration, this one describes the science behind our paper and a second one by Nelson, which just appeared in PLoS Genetics.

Laboratories around the world are generating a tsunami of deep-sequencing data from nearly every organism, past and present.

Data Diving for Genomics Treasure

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I want to use this functionality to re-blog a few posts from the archives during the month of august while I’m away. This is the first post in this series, just to see if it works and what needs to be tweaked.

Flashback: The neurobiology of self-learning

Yesterday, Alex Kacelnik published yet another fascinating discovery – one of many over the years out of his lab. This time, they show how birds can pick even five consecutive locks to get to a food reward:  According to the authors, the birds solve this problem by trial and error, i.e., in the operant, goal-directed way, which is the learning mechanism we study in our lab.

…and now for some lock-picking cockatoos

There can be little doubt that the defunding of public academic institutions is a main staple of populist movements today. Whether it is Trump’s budget director directly asking if one really needs publicly funded science at all, or the planned defunding of the endowments of arts and humanities or the initiatives to completely abolish the EPA and other science agencies.

Are we inadvertently supporting the defunding of public science?

This is our first poster at this year’s SfN meeting in San Diego. It’s about decision-making in fruit flies. We find a probabilistic form of decision-making that suggests that without understanding the mechanisms behind this fundamental uncertainty, we will never fully understand decision-making. Clicking on the image will let you download the PDF Version of the poster.

Do flies in groups make individual choices?

I usually don’t write about politics, but there has been one or the other exception to this rule in the last 12 years of this blog. This time, I’ve been missing one particular response to the various terrorist attacks in recent times, perhaps one of the few readers of this obscure blog has found it somewhere and can point me in this direction?

Have you seen this response to terrorism anywhere?

UPDATE

: I’m still not completely sure I understood Churchland accurately, but there are comments suggesting I may just have completely misunderstood her replies to the interviewer. Read the interview and judge for yourself! I really like Patricia Churchland.

[updated]Churchland: “Ignore science and live a make-believe life!”

In the process of migrating content from the old site to WordPress, I’m also moving some articles from there and re-publishing them here as posts. This one is such a case, originally published on December 7, 2006.

Brains as output/input systems

Update, Dec. 4, 2015: With the online discussion moving towards grantsmanship and the decision of what level of expertise to expect from a reviewer, I have written down some thoughts on this angle of the discussion.

With more and more evaluations, assessments and quality control, the peer-review burden has skyrocketed in recent years.

Why cutting down on peer-review will improve it

This is a post loosely based on an article appearing today in the German newspaper “Frankfurter Allgemeine Zeitung” by Axel Brennicke and me. The raw data for our analysis is available. Please do let us know if you find a mistake.


 UPDATE

*, 09/01/2015: A commenter made me aware of data rows in the raw data we had overlooked before.

Booming university administrations

Rejection is one of the unpleasant but inevitable components of life. There are positive components to rejection: they build character, they force you to deal with negativity and sometimes they force you to change your life to avoid future rejections.

The cost of the rejection-resubmission cycle

At seemingly every possibility in a discussion on peer-review, people apparently feel the need to emphasize that in the current model reviewers (or most academic editors handling peer-review) are not being paid.

Peer-review is not free – it’s a subsidy for publishers

On May 23, the Council of the EU adopted a set of conclusions on scholarly publishing that, if followed through, would spell the end for academic publishers and scholarly journals as we know them. On the same day, the adoption was followed by a joint statement of support by the largest and most influential research organizations in Europe.

The beginning of the end for academic publishers?

To my knowledge, no neuroscientist hypothesizes that there is magic in our heads. However, it appears this is a hypothesis that flies by the editors at the New York Times.

Free will:  it’s not what you think it is

This year marks the 12th anniversary of the publication of this legendary letter to the editor in the Journal of systems and Software:  Nothing really has changed in a dozen years, it seems

12 year anniversary of angry letter to scientific journal editor

Barely a fortnight has passed since

 Science Magazine

published the outcomes of a hoax perpetrated by one of their reporters, John Bohannon. Not surprisingly, the news article was widely criticized, not the least on this obscure blog. The content was simple enough: Bohannon picked a swath of largely fake journals, submitted fake manuscripts and boasted that more than 60% of his submissions were accepted.

Not to be outdone, Nature Magazine rejects data, publishes opinion

Just before Christmas 2019, the Washington Post reported, based on “people familiar with the matter”, that the US Justice Department were investigating the Sci-Hub founder Alexandra Elbakyan for potentially “working with Russian intelligence to steal U.S. military secrets from defense contractors”. Besides such a highly unusual connection, the article also reiterated unsubstantiated (but mainly circulated by publishers) allegations that access

Is the SNSI the new PRISM?

Jeffrey “predatory journals” Beall famously catapulted himself out of any serious debate with an article in the journal TripleC, entitled “The Open-Access Movement is Not Really about Open Access”. In it, Beall claimed that OA proponents don’t care about access, but that they form an “anti-corporatist movement that wants to deny the freedom of the press to companies it disagrees with”. The article is so replete with similarly unhinged fairy

Is this Smits’ tripleC moment?

Open Access (OA) pioneer and OA journal eLife founding member and sponsor, the Max Planck Society just released a white paper (PDF) analyzing open access costs in various countries and institutions and comparing them to subscription costs. Such studies are fundamental prerequisites for evidence-based policies and informed decisions on how to proceed with bitterly needed reforms.

A study justifying waste of tax-funds?

Scholarly journals, on the face of it, emerged in the 17

 th

century as a medium to facilitate communication of scientific discoveries among interested scholars. In the 21

 st

century, it’s not all that different: researchers form communities around topics in which they share a common interest: Journal of Neuroscience, Pediatrics and Neonatology, Journal of Economics or the British Educational Research Journal.

Academic publishers and competition

This post was originally published on the London School of Economics “Impact of Social Sciences” blog, on July 30, 2013:

In various fields of scholarship, scholars accrue reputation via the proxy of the containers they publish their articles in. In most if not all fields, scholarly journals are ranked in a hierarchy of prestige.

Solutions to the looming crisis in science

In her recent editorial on Sci-Hub (an initiative I support), editor-in-chief of

 Science Magazine

Marcia McNutt wrote: The editorial is essentially trying to make the somewhat tenuous but not implausible case that using sci-hub may lead to subscription cancellations which, in turn, may lead to scholarly societies (like those of Dr. McNutts employer, AAAS) to miss revenue they need in order to pay for important services (such as paying

In which a Science editorial demonstrates the ineffectiveness of OA activism

Over the years, publishers have left some astonishingly frank remarks over how they see their role in serving the scholarly community with their communication and dissemination needs. This morning, I decided to cherry-pick some of them, take them out of context to create a completely unrealistic caricature of publishers that couldn’t be further from the truth.

How do academic publishers see their role?

You’d be forgiven if after reading the title of this post, you thought scholars have started to revolt against journal rank. Unfortunately, while there is DORA and of course the evidence that journal rank is like homeopathy, most researchers are still fine with ex-scientists rejecting 92% of all submitted articles and charging a grand sum of more than US$30,000 per article that they select on a whim.

Publisher selects the best open access science – authors complain

Earning credibility in post-factual science?

This morning I was reminded of the age of some of the technology we’re using. Hyperlinks were developed at Stanford University and first demonstrated by their inventor Douglas Engelbart (using the first mouse) in 1968:  On Tuesday, Douglas Engelbart died, even before the scholarly literature was able to fully implement the technology he invented, 45 years and counting.

The dysfunctionality of the scholarly literature: hyperlinks

Scientists as social parasites?

Time and time again, academic publishers have managed to create the impression that publishing incurs a lot of costs which justify the outrageous prices they charge, be that US$11M p.a. for an

 Elsevier

Big Deal subscription or an article processing charge (APC) of US$5,200 for a

 Nature Communications

article.

How publishers keep fooling academics

I have now posted the job ads for the PostDoc position in our lab at

 Nature

,

 Science

, SfN and FENS.

PostDoc opportunity in our lab now advertized

As a regular user of the scholarly literature since before the internet (I started reading primary scientific literature for a high-school project around 1989), I have closely followed its digitization.

7 functionalities the scholarly literature should have

See this post with the associated press releases on brembs.net.

The

 F

orkhead B

 ox

P2 (FOXP2) gene is well-known for its involvement in language disorders. We have discovered that a relative of this gene in fruit flies,

 dFoxP

, is necessary for a type of learning called operant self-learning, which resembles some aspects of language learning.

The Drosophila FoxP gene is necessary for operant self-learning

Over the last ten years, scientific funding agencies across the globe have implemented policies which force their grant recipients to behave in a compliant way. For instance, the NIH OA policy mandates that research articles describing research they funded must be available via PubMedCentral within 12 months of publication. Other funders and also some institutions have implemented various policies with similar mandates.

Maybe try another kind of mandate?

The cost of knowledge – in 2003?

It’s the time of the year again where 30,000 neuroscientists head to the US to talk neuroscience. This year the big annual conference is in Washington, DC, one of the three cities able to host this large event. Our first poster will be up on Tuesday morning and shows results from operant self-stimulation experiments using optogenetics and dopaminergic neurons.

Heading for #SfN23 with two posters

There are regular discussions among academics as to who should be the prime mover in infrastructure reform. Some point to the publishers to finally change their business model. Others claim that researchers need to vote with their feet and change how they publish. Again others find that libraries should just stop subscribing to journals and use the saved money for a modern publishing system.

Who’s responsible for the lack of action?

Yesterday, cOAlition S published their updated principles and implementation guidelines for #PlanS, together with the rationale behind the update. This constitutes a very much welcome effort, as evidence of the increasing awareness among funders as to their potential leverage in infrastructure modernization, at a time when institutions have apparently abandoned their faculty completely.

Improved Plan S principles raise hope of more effective policies soon

The recent publication of the “Ten Principles of Plan S” has sparked numerous discussions among which one of several recurring themes was academic freedom. The cause for these discussions is the insistence of the funders supporting Plan S that their grant recipients only publish in certain venues under certain liberal licensing schemes.

Does academic freedom entail exemption from spending rules?

In his fantastic Peters Memorial Lecture on occasion of receiving CNI’s Paul Evan Peters award, Herbert Van de Sompel of Los Alamos National Laboratory described my calls to drop subscriptions as “radical” and “extremist” (starting at about minute 58):  Regardless of what Herbert called my views, this is a must-see presentation in which Herbert essentially presents the technology and standards behind the functionalities I have been asking for

Why academic journals need to go

“an academic career, in which a person is forced to produce scientific writings in great amounts, creates a danger of intellectual superficiality”

Albert Einstein Isaacson W (2008) Einstein (His Life and Universe) (Simon and Schuster, New York), 1st Ed, p 79

On the productivity of scientists

This is the tweetlog covering July 3-5: Interesting! We find something similar in flies: Live fast, die young: Long-lived mice are less active https://feedly.com/k/16RDz21 It smells fishy: Copper prevents fish from avoiding danger https://feedly.com/k/12gw14F @

 biocs

@

 google

Yes!

Tweetlog: neuroscience and #openaccess

In the last “Science Weekly” podcast from the Guardian, the topic was retractions.  At about 20:29 into the episode, Hannah Devlin asked, whether the reason ‘top’ journals retract more articles may be because of increased scrutiny there. The underlying assumption is very reasonable, as many more eyes see each paper in such journals and the motivation to shoot down such high-profile papers might also be higher.

Are more retractions due to more scrutiny?

Until today, I was quite proud of myself for not caving in to SIWOTI syndrome like Mike Taylor did. And then I read his post and caved in as well. What gets us so riled up is Elsevier’s latest in a long list of demonstration of what they think of the intellectual capacities of their customers. It’s precisely because it is only one in a long row that I initially didn’t feel like commenting.

Is this supposed to be the best Elsevier can muster?

For ages I have been planning to collect some of the main aspects I would like to see improved in an upgrade to the disaster we so euphemistically call an academic publishing system. In this post I’ll try to briefly sketch some of the main issues, from several different perspectives.

 As a reader:

I’d like to get a newspaper each morning that tells me about the latest developments, both in terms of general science news (aka.

What should a modern scientific infrastructure look like?

I really loathe reviewing for GlamMagz for two main reasons. For one, it’s hard to remain neutral: publication of a paper in my field in such a journal is beneficial both for the field and for the young people who are authors on this paper. Second, the demands of some of my colleagues so often make my blood boil. At that point I’m very happy these reviews are anonymous and I really don’t want to know the names of these colleagues.

Why this GlamMag will likely not ask for my review again

For our course this year I was planning a standard neurogenetic experiment. I hadn’t ever done this experiment in a course, yet, just two weeks ago I tried it once myself, with an N=1. The students would get two groups of

 Drosophila

fruit fly larvae, rovers and sitters (they wouldn’t know which was which). About ten larvae from each group would be placed on one of two yeast patches on an agar plate.

If only all science were this reproducible

Random Science Video: The value of fly research

Last week, Elizabeth Pennisi asked me to comment on the recent paper from Schreiweis

 et al.

entitled “Humanized FoxP2 accelerates learning by enhancing transitions from declarative to procedural performance”. Since I don’t know how much, if anything, of my answers to her questions will end up in her article, I thought I might expand my answer into a post about this very interesting work.

Humanized FoxP2 and the timing of habits

This is an easy calculation: for each subscription article, we pay on average US$5000. A publicly accessible article in one of SciELO’s 900 journals costs only US$90 on average. Subtracting about 35% in publisher profits, the remaining difference between legacy and SciELO costs amount to US$3160 per article.

Are we paying US$3000 per article just for paywalls?

The data clearly show that publications in

 Cell

,

 Nature

or

 Science

(

 CNS

for short), on average, cannot be distinguished from other publications, be it by methodology, reproducibility or other measures of quality. Even their citation advantage, while statistically significant, is so small that it is practically negligible.

No need to only send your best work to Science Magazine

There is an interesting study out in the journal PNAS: “Evaluating big deal journal bundles”. The study details the disparity in negotiation skills between different US institutions when haggling with publishers about subscription pricing.

Your university is definitely paying too much for journals

The other day I was alerted to an interesting evaluation of international citation data. The author, Curt Rice, mentions a particular aspect of the data:  The context here is that the “bottom” refers to scientific articles that aren’t cited, assuming that no citations mean low scientific quality of that article.

Citation inflation and incompetent scientists

Genetically Separable" href="https://www.slideshare.net/brembs/wcalb14" target="_blank"&gt;Pavlovian and Skinnerian Processes are Genetically Separable

Two evolutionary conserved, fundamental learning mechanisms

Sven Fund, CEO of the German publishing house de Gruyter was recently interviewed by Richard Poynder in his widely read interview series on open access. In the interview, he first avoided answering the question if de Gruyter had ever lobbied against open access.

Is de Gruyter’s lobby-by-proxy not lobbyism?

I just got the nicest decline to review ever:  That’s how you retire from science: you get to work like normal people. Awesome!

Retiring from science?

It is one of these rare events when I can post a video of one of my own talks. This one was in Berlin earlier this year, organized by The Lost Lectures in a very unusual venue, the Stattbad Wedding:  I’m planning to work more closely together with our computing center here to be able to record at least the lectures I give in English here at the university. So maybe there will be some more videos here, soon.

Video: Free will as an evolved brain function

Since the birth of our daughter, we spend our summers in Sweden, just like I used to, when I was little. This not only allows her to get more practice in Swedish then she gets talking with just me or her grandmother, but we also get to really recharge our batteries in the fabulous wilderness up there.

How to recharge in Sweden

A fistful of dollars: why corporate publishers have no place in scholarly communication

Following the example of Glyn Moody, I thought I’d start a log on the tweets I send around. One never knows what’ll happen to Twitter and besides, this provides a neat place to store and find everything. So here are the tweets for July first and second: Where are we, what still needs to be done?

Trying a new feature: Tweetlog

Flashback: All brains possess free will because there is no design in biology

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away.

Science, red in tooth and claw

*During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away. This post is from February 9, 2011: *     In this week’s journal club, we talked about an old paper from 1918!

Flashback: Nothing new in science?

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away. This post is from April 19, 2011:

Flashback: Creationists, this is the evidence you have to beat!

*As part of my scheduled re-posts during the summer break, I’ll also post some of the science videos from the archives. I originally posted this one on Agust 31, 2011: *

SummerScienceVideo: science is real

It might just save your life (via Upturned Microscope):    BTW, even if your life is not at stake, someone else’s may be. So you should publish your results if you are sure something definitely will not work, for instance in F1000 Research, where you can publish negative results for free until August 31, 2013. Your colleagues will be grateful.

One more reason to publish negative results

The recently released development draft for SHared Access Research Ecosystem (SHARE), authored by the Association of American Universities (AAU), the Association of Public and Land-grant Universities (APLU) and the Association of Research Libraries (ARL) in response to the OSTP memo on public access to federally funded research in the US sounds a lot like the library-based publishing system I’ve been perpetually arguing for.

SHARE: Library-based publishing becoming a reality?

Academic publishers have been parasitizing the public purse for long enough now. Steffen Böhm, director of the Essex Sustainability Institute, said it best: In his article, he mentions the successful SciELO project in South America. In a lot of ways, SciELO (scielo.org) is quite close to what I have been arguing for: SciELO means “Scientific Electronic

 Library

Online” and is supported by the Brazilian and Chilean government.

Cut out the parasitic middle men!

This year’s Winter Conference on Animal Learning and Behavior (WCALB) will be on one of my oldest and most central research projects, the commonalities and differences between operant and classical conditioning.

Almost 80 years on, progress on operant and classical conditioning

Amazing bead chain experiment

No matter how well-intended (and we all know to which place the road leads that is paved with good intentions!), transformative agreements (such as DEAL in Germany) are generally the wrong tool at the wrong time for making publicly funded science accessible to the public.

No Evilsevier DEAL!

The DFG is a very progressive and modern funding agency. More than two years ago, the main German science funding agency signed the “Declaration on Research Assessment” DORA.

German funder DFG: Why the sudden inconsistency?

tl;dr:
 
 It is a waste to spend more than the equivalent of US$100 in tax funds on a scholarly article.

Collectively, the world’s public purse currently spends the equivalent of US$~10b every year on scholarly journal publishing. Dividing that by the roughly two million articles published annually, you arrive at an average cost per scholarly journal article of about US$5,000.

How much should a scholarly article cost the taxpayer?

Today, our most recent paper got published, before traditional peer-review, at

 F1000 Research

. The research is about how nominally identical fly stocks can behave completely differently even if tested by the same person in the same lab in the same test.

The way academic publishing should be

UPDATE
 
 , 10-02-2015: After a hint from a user on Twitter, I now know that it is possible to open a PDF document in several windows, one for text, one for legends and one for figures. Figures and legends occupy one virtual desktop and the text another. In this way, I can actually review on-screen, but it is one heck of a work-around and by no means convenient.

I cannot take it any more.

Publishers, stop torturing your reviewers!

This is a slightly edited (amended, essentially) version of

my article published today at The Conversation. In cases where a problem within a community is detected and collective action is required to address the problem. one needs to strike a fine line or any efforts to convince the community that action is required will fail.

The Conversation: The looming crisis in science

You may have seen a neutered version of this post over at the LSE blog. This post below, however, puts the tiger in the tank, as it was enhanced by CatGPT:  Maybe scholarly societies have taken “the instruction“follow the money!” a tad too literally?

Scholarly societies: like a cat chasing the laser dot

The recent call for a GlamMag boycott by Nobel laureate Randy Shekman made a lot of headlines, but will likely have no effect whatsoever. For one, the call for boycott isn’t even close in scale to “the cost of knowledge” boycott against Elsevier and even that drew less than 15,000 measly signatures, a drop in the bucket with 970,000 board members, reviewers and authors working for Elsevier largely for free.

In support of subscripton cancellations

Currently, our libraries are paying about US$5000 per peer-reviewed subscription article. What is more difficult to find out is where all that money goes. Which steps are required to make an accepted manuscript public?

What goes into making a scientific manuscript public?

Talk about egg on face!

 Nature

“the world’s best science”

 Magazine

sets out to publish back-to-back papers on – of all topics – stem cell science.

Even the most thorough peer-review at the ‘best’ journals not up to snuff?

Public institutions the world over are required to spend their funds responsibly. Commonly, this is done by requiring them to host bids for purchases or services above a certain threshold. If you work at a public institution and have wondered, e.g., why you are only allowed to buy a computer from your computing facility which only sells one particular brand, then the answer likely is that this brand won the bidding contest.

Should public institutions not be choosing the lowest responsible bidder?

The recently discussed scenario of universal gold open access brought about by simply switching the subscriptions funds at libraries to have the libraries pay for author processing charges instead, seemed like a ghoulish nightmare. One of the few scenarios worse than the desolate state we call the

 status quo

today.

Whither now, Open Access?

Flashback: What can the spine teach us about learning?

Flashback: The neurobiology of operant conditioning

Our lab is looking for a PhD student interested in the molecular mechanisms of operant self-learning, a form of motor learning.

Looking for a PhD student

After Mike Taylor kept complaining about how horrible my old e107 platform was (which obviously it isn’t: I love this CMS), I finally gave in and moved everything over to a new home. The entire brembs.net domain with all its subdomains is no longer hosted in the good old US of A, where its home was since about 2000, when I moved there myself. After almost ten years back in Germany, I’ve now brought my online presence back home as well.

A new home for bjoern.brembs.blog

I recently was sent a report from a university-wide working group on the publishing habits within the Freie Universität Berlin. I don’t think this document is available online, but I think I’m not doing anything illegal if I publish some of the survey results here. The working group polled all faculty members of the university on various questions concerning scholarly publishing.

How important is the Impact Factor?

Think, check, submit: who hasn’t heard of this mantra to help researchers navigate the jungle of commercial publishers? Who isn’t under obligation to publish in certain venues, be it because employers ask for a particular set of journals for hiring, tenure or promotion, or because of funders’ open access mandates?

How academic institutions neglect their duty

The academic journal publishing system sure feels all too often a bit like a sinking boat: we have a reproducibility leak an affordability leak a functionality leak a data leak a code leak an interoperability leak a discoverability leak a peer-review leak a long-term preservation leak a link rot leak an evaluation/assessment leak a data visualization leak … … … and even a tiny access leak still remains even after 30 years of trying to fix it.

Scholarly publishing in three cartoons

bjoern.brembs.blog

I was very excited when our [latest research
paper](https://doi.org/10.12688/f1000research.146347.2) came out, after
all, I was confident our [30-year-long
search](https://bjoern.brembs.net/2024/01/the-speed-or-lack-thereof-of-science/)
for the sites of plasticity in the form of motor learning we study was
coming to an end. In this work, we were fairly confident that underlying
the type of learning we study was a novel form of plasticity in a very
specific set of motor neurons in the ventral nerve cord of the flies we
use for our research. The reason for our confidence was the convergence
of several lines of genetic evidence:

- inhibiting all PKCs (protein kinase C) in motor neurons abolished
 motor learning
- knocking-out just aPKC (atypical PKC) in motor neurons also abolished
 motor learning
- knocking out aPKC in neurons that also express the gene FoxP abolished
 motor learning (and FoxP is also expressed in motor neurons and itself
 necessary for motor learning)
- knocking-out FoxP outside of the ventral nerve cord had no effect

In addition to these genetic lines of evidence, we looked at the
expression patterns of the two genes we know are required for motor
learning: aPKC and FoxP.
[\#3](https://bjoern.brembs.net/tag/3/){.hashtag .u-tag .u-category
rel="tag"} in the list of genetic evidence above suggests that aPKC is
required in FoxP neurons, so we looked for neurons in the fly nervous
system that co-express both aPKC and FoxP. The first finding was that
there don't seem to be any such co-expressing neurons in the brain, just
in the ventral nerve cord. We (and by 'we' I mean our collaborator in
Mainz, motor neuron expert Carsten Duch) identified some of those
co-expressing neurons in the ventral nerve cord to be the steering motor
neurons that control the muscles that position the wings during turning
maneuvers. This last bit made us all excited: in our motor learning
task, we train flies to make specific turning maneuvers, i.e., left or
right turns, respectively. In our experiments, before we train the
animals, they make just as many left turns as they make right turns.
Then we train them to just do one kind of turns, such that, after
training, the flies preferentially turn into the, say, right direction,
if that was the side they've been trained to do. Finding that the motor
neurons involved in these kinds of behaviors also expressed both aPKC
and FoxP supported the genetic evidence that these neurons may be where
the plasticity underlying the learning may reside. However, there aren't
the genetic tools available at the moment (they are being created as I
type this) to specifically manipulate plasticity in just these neurons
and no other neurons, so while all the evidence was pointing towards
them, we couldn't be quite sure, yet. There may be other neurons
involved that we just didn't have on our radar, yet.

There is another behavior that also involved these steering motor
neurons and that is the "optomotor response" (OMR). Almost all animals
show OMRs to moving stimuli: if you sit in a car or train and look
outside to the passing landscape, your eyes will show the typical rapid
movements (nystagmus) when trying to stabilize the moving image on your
retina. Other animals move not just their eyes, but also their heads to
stabilize the image, again others move their eyes, heads and sometimes
also the rest of the body to, say, a rotating stimulus around them (or
if they are rotated). Flies flying stationarily at a tether presented
with vertical stripes moving around them either towards the left (i.e.,
counterclockwise, if seen from above) or right (clockwise, from above),
respectively, will try to follow the stripes and generate turning
maneuvers in the same direction: the optomotor response. It's known that
in order to execute these elicited turning maneuvers, there are neurons
in the brains of the animals that send the information about the
rotating stimuli directly to the steering motor neurons, bypassing all
other neurons on the way. This means that they also bypass those neurons
that are used to generate the spontaneous turning maneuvers we train the
flies to perform in our motor learning paradigm.

Essentially, the only part of the nervous system, where the OMRs overlap
with the behaviors we train are these steering motor neurons. This means
that if these steering motor neurons are modified by our motor learning,
as all the evidence described above suggests, we should se some
modulation of the OMR after motor learning. Our
[paper](https://doi.org/10.12688/f1000research.146347.2) shows the data
where exactly such a modulation can be observed. So with this data we
were fairly convinced that the plasticity we have been searching for in
all these decades was indeed in the steering motor neurons. But we
weren't quite certain, yet. What was missing? Because we had so far only
observed the modulation of the OMR in wild type animals, we didn't know
if the manipulations of the FoxP and aPKC that abolish motor learning
would also abolish the modulation of the OMR. Now we finally also have
that piece of the puzzle!

We again used the CRISPR/Cas9 technique to knock out aPKC on
FoxP-positive neurons. These flies were first tested for their OMR
before training, then subjected to motor learning of either left or
right turning maneuvers, respectively, and finally tested for their OMR
again. The genetic control flies that carried the same genetic
constructs, but in a dysfunctional way so aPKC expression would not be
affected were subjected to the same OMR-ML-OMR regime. The initial OMR
between both groups was identical. The motor learning phase showed the
same defiicit as we had observed with these flies in our paper:

<figure class="wp-block-image size-large is-resized">
<a
href="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled.png"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-896x1024.png"
class="wp-image-2860" style="width:840px;height:auto"
data-fetchpriority="high" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-896x1024.png 896w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-263x300.png 263w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-768x878.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-44x50.png 44w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled.png 1344w"
sizes="(max-width: 896px) 100vw, 896px" width="896" height="1024" /></a>
</figure>

The two control groups (blue and green) show a preference for the
unpunished turning direction that is significant both in frequentist
(Wilcoxon) and Bayesian (Bayes Factor, bf) statistics against zero (no
preference), while the aPKC knock-outs (yellow) show no such preference.
We replicated our finding that knocking-out aPKC in FoxP-neurons
abolishes motor learning.

To compare the controls with the knock-outs, we pooled the controls and
separately analyzed the OMR of those flies that were punished for
left-turning maneuvers and those that were punished for right-turning
maneuvers, respectively:

<figure class="wp-block-image size-large is-resized">
<a
href="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1.png"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-1024x614.png"
class="wp-image-2861" style="width:840px;height:auto" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-1024x614.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-300x180.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-768x461.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-1536x922.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1-50x30.png 50w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-1.png 1920w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024"
height="614" /></a>
</figure>

The control flies (above) show the modulation of the OMR that we had
already seen in wild-type flies: animals punished for left turns showed
a reduced OMR for left-turning stimuli and vice versa for flies punished
for left turns. Quantifying this asymmetry shows us that flies punished
on left turns show an asymmetry shifted to the right (i.e., positive
values), compared to flies punished on right turns, who are relatively
more negative (i.e., shifted to the left):

<figure class="wp-block-image size-large">
<a
href="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2.png"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-1024x512.png"
class="wp-image-2862" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-1024x512.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-300x150.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-768x384.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-1536x768.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-2048x1024.png 2048w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-2-50x25.png 50w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024"
height="512" /></a>
</figure>

In contrast, this quantification in the knock-outs looks a lot more
symmetrical:

<figure class="wp-block-image size-large">
<img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-1024x512.png"
class="wp-image-2864" loading="lazy" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-1024x512.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-300x150.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-768x384.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-1536x768.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-2048x1024.png 2048w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/Untitled-4-50x25.png 50w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024" height="512" />
</figure>

If one now takes this measure of asymmetry and changes the signs such
that positive doesn't mean "right turns" any more, but "unpunished
turning direction", then we can compare the OMR modulation directly to
the trained turning preference in a single figure:

<figure class="wp-block-image size-large is-resized">
<img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-1024x818.png"
class="wp-image-2865" style="width:840px;height:auto" loading="lazy"
decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-1024x818.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-300x240.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-768x614.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-1536x1228.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image-50x40.png 50w, https://bjoern.brembs.net/wp/wp-content/uploads/2024/07/image.png 1629w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024" height="818" />
</figure>

The pooled genetic controls (A) show both a significant OMR modulation
(blue, left) and a significant turning preference (yellow, right), while
the aPKC knock-outs (B) show neither.

So with this data, we are now really quite sure that plasticity in
steering motor neurons is one way in which this type of motor learning
manifests itself in the nervous system.

I was very excited when our latest research paper came out, after all, I was confident our 30-year-long search for the sites of plasticity in the form of motor learning we study was coming to an end. In this work, we were fairly confident that underlying the type of learning we study was a novel form of plasticity in a very specific set of motor neurons in the ventral nerve cord of the flies we use for our research.

bjoern.brembs.blog

Whodathunk? Motor learning in motor neurons, huh?