Björn Brembs

So this is essentially what happened instead of us sitting down and thinking how we could spend our money in the most technologically savvy way to the benefit of science, scholars and society. A generation later, roughly US$300 billion poorer and none the wiser, it seems.

The ultimate Open Access timeline

tl;dr: So far, I can’t see any principal difference between our three kinds of intellectual output: software, data and texts.   I admit I’m somewhat surprised that there appears to be a need to write this post in 2014. After all, this is not really the dawn of the digital age any more.

What is the difference between text, data and code?

Lately, there has been some public dreaming going on about how one could just switch to open access publishing by converting subscription funds to author processing charges (APCs) and we’d have universal open access and the whole world would rejoice. Given that current average APCs have been found to be somewhat lower than current subscription costs (approx.

What happens to publishers that don’t maximize their profit?

Trial and error is a successful problem-solving strategy not only in humans but throughout evolution. How do nervous systems generate novel, creative trials and how are errors incorporated into already existing experiences in order to improve future trials?

Come and do research with us!

While the first day (day 2, day 3) was dominated by philosophy, mathematics and other abstract discussions of chance, this day of our symposium started with a distinct biological focus.

 Martin Heisenberg, Chance in brain and behavior

First speaker for this second day on the symposium on the role of chance in the living world was my thesis supervisor and mentor, Martin Heisenberg.

Chance in animate nature, day 2

While our own manuscript on journal rank is almost through the peer-review process, this morning I received several messages announcing the DORA (

 San Francisco declaration on research Assessment

), which I signed immediately.

Official call for an end to journal rank

*During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away.

Flashback: Programming Free Will – creative robots

For 14 years, the main research funding agency in Germany, the German Research Foundation (DFG) has stated in its guidelines that submitted grant proposals will be assessed primarily on the basis of their

 content

, rather than counting the applicants’ previous publications. However, not all of DFG’s panels seem to be on board.

Research assessment: new panels, new luck?

Notwithstanding the barrage of criticisms and warnings from every corner of the scholarly community, various initiatives, mainly in the Netherlands, Finland, Germany, France and the UK, continue their efforts for a smooth transition from subscriptions to open access without any further disruptions.

Why open access Big Deals are worse than subscriptions

When I finished my PhD 15 years ago, the neurosciences defined the main function of brains in terms of processing input to compute output: “brain function is ultimately best understood in terms of input/output transformations and how they are produced” wrote Mike Mauk in 2000 (DOI: 10.1038/76606). Since then, a lot of things have been discovered that make this stimulus-response concept untenable and potentially based largely on laboratory

Watching a paradigm shift in neuroscience

Over the weekend, I received the following short message from a Hotmail account:  This email is full of signs that the student may not have been all that interested in any information or discourse, but instead trying to make some sort of ‘gotcha’ statement. Curiously, the author first states that their scientific training is lacking and then they disagree with a scientific position.

How not to contact faculty as student

With the start of the new year 2017, about 60 universities and other research institutions in Germany are set to lose subscription access to one of the main STEM publishers, Elsevier. The reason being negotiations of the DEAL consortium (600 institutions in total) with the publisher.

So your institute went cold turkey on publisher X. What now?

In what area of scholarship are repeated replications of always the same experiment every time published and then received with surprise, only to immediately be completely ignored until the next study? Point in case from an area that ought to be relevant to almost every single scientist on the planet: research evaluation.

How scientific are scientists, really?

This is a post written jointly by Nelson Lau from Brandeis and me, Björn Brembs. In contrast to Nelson’s guest post, which focused on the open data aspect of our collaboration, this one describes the science behind our paper and a second one by Nelson, which just appeared in PLoS Genetics.

Laboratories around the world are generating a tsunami of deep-sequencing data from nearly every organism, past and present.

Data Diving for Genomics Treasure

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I want to use this functionality to re-blog a few posts from the archives during the month of august while I’m away. This is the first post in this series, just to see if it works and what needs to be tweaked.

Flashback: The neurobiology of self-learning

Yesterday, Alex Kacelnik published yet another fascinating discovery – one of many over the years out of his lab. This time, they show how birds can pick even five consecutive locks to get to a food reward:  According to the authors, the birds solve this problem by trial and error, i.e., in the operant, goal-directed way, which is the learning mechanism we study in our lab.

…and now for some lock-picking cockatoos

There can be little doubt that the defunding of public academic institutions is a main staple of populist movements today. Whether it is Trump’s budget director directly asking if one really needs publicly funded science at all, or the planned defunding of the endowments of arts and humanities or the initiatives to completely abolish the EPA and other science agencies.

Are we inadvertently supporting the defunding of public science?

This is our first poster at this year’s SfN meeting in San Diego. It’s about decision-making in fruit flies. We find a probabilistic form of decision-making that suggests that without understanding the mechanisms behind this fundamental uncertainty, we will never fully understand decision-making. Clicking on the image will let you download the PDF Version of the poster.

Do flies in groups make individual choices?

I usually don’t write about politics, but there has been one or the other exception to this rule in the last 12 years of this blog. This time, I’ve been missing one particular response to the various terrorist attacks in recent times, perhaps one of the few readers of this obscure blog has found it somewhere and can point me in this direction?

Have you seen this response to terrorism anywhere?

UPDATE

: I’m still not completely sure I understood Churchland accurately, but there are comments suggesting I may just have completely misunderstood her replies to the interviewer. Read the interview and judge for yourself! I really like Patricia Churchland.

[updated]Churchland: “Ignore science and live a make-believe life!”

In the process of migrating content from the old site to WordPress, I’m also moving some articles from there and re-publishing them here as posts. This one is such a case, originally published on December 7, 2006.

Brains as output/input systems

Update, Dec. 4, 2015: With the online discussion moving towards grantsmanship and the decision of what level of expertise to expect from a reviewer, I have written down some thoughts on this angle of the discussion.

With more and more evaluations, assessments and quality control, the peer-review burden has skyrocketed in recent years.

Why cutting down on peer-review will improve it

This is a post loosely based on an article appearing today in the German newspaper “Frankfurter Allgemeine Zeitung” by Axel Brennicke and me. The raw data for our analysis is available. Please do let us know if you find a mistake.


 UPDATE

*, 09/01/2015: A commenter made me aware of data rows in the raw data we had overlooked before.

Booming university administrations

Rejection is one of the unpleasant but inevitable components of life. There are positive components to rejection: they build character, they force you to deal with negativity and sometimes they force you to change your life to avoid future rejections.

The cost of the rejection-resubmission cycle

At seemingly every possibility in a discussion on peer-review, people apparently feel the need to emphasize that in the current model reviewers (or most academic editors handling peer-review) are not being paid.

Peer-review is not free – it’s a subsidy for publishers

On May 23, the Council of the EU adopted a set of conclusions on scholarly publishing that, if followed through, would spell the end for academic publishers and scholarly journals as we know them. On the same day, the adoption was followed by a joint statement of support by the largest and most influential research organizations in Europe.

The beginning of the end for academic publishers?

To my knowledge, no neuroscientist hypothesizes that there is magic in our heads. However, it appears this is a hypothesis that flies by the editors at the New York Times.

Free will:  it’s not what you think it is

This year marks the 12th anniversary of the publication of this legendary letter to the editor in the Journal of systems and Software:  Nothing really has changed in a dozen years, it seems

12 year anniversary of angry letter to scientific journal editor

Barely a fortnight has passed since

 Science Magazine

published the outcomes of a hoax perpetrated by one of their reporters, John Bohannon. Not surprisingly, the news article was widely criticized, not the least on this obscure blog. The content was simple enough: Bohannon picked a swath of largely fake journals, submitted fake manuscripts and boasted that more than 60% of his submissions were accepted.

Not to be outdone, Nature Magazine rejects data, publishes opinion

Just before Christmas 2019, the Washington Post reported, based on “people familiar with the matter”, that the US Justice Department were investigating the Sci-Hub founder Alexandra Elbakyan for potentially “working with Russian intelligence to steal U.S. military secrets from defense contractors”. Besides such a highly unusual connection, the article also reiterated unsubstantiated (but mainly circulated by publishers) allegations that access

Is the SNSI the new PRISM?

Jeffrey “predatory journals” Beall famously catapulted himself out of any serious debate with an article in the journal TripleC, entitled “The Open-Access Movement is Not Really about Open Access”. In it, Beall claimed that OA proponents don’t care about access, but that they form an “anti-corporatist movement that wants to deny the freedom of the press to companies it disagrees with”. The article is so replete with similarly unhinged fairy

Is this Smits’ tripleC moment?

Open Access (OA) pioneer and OA journal eLife founding member and sponsor, the Max Planck Society just released a white paper (PDF) analyzing open access costs in various countries and institutions and comparing them to subscription costs. Such studies are fundamental prerequisites for evidence-based policies and informed decisions on how to proceed with bitterly needed reforms.

A study justifying waste of tax-funds?

Scholarly journals, on the face of it, emerged in the 17

 th

century as a medium to facilitate communication of scientific discoveries among interested scholars. In the 21

 st

century, it’s not all that different: researchers form communities around topics in which they share a common interest: Journal of Neuroscience, Pediatrics and Neonatology, Journal of Economics or the British Educational Research Journal.

Academic publishers and competition

This post was originally published on the London School of Economics “Impact of Social Sciences” blog, on July 30, 2013:

In various fields of scholarship, scholars accrue reputation via the proxy of the containers they publish their articles in. In most if not all fields, scholarly journals are ranked in a hierarchy of prestige.

Solutions to the looming crisis in science

In her recent editorial on Sci-Hub (an initiative I support), editor-in-chief of

 Science Magazine

Marcia McNutt wrote: The editorial is essentially trying to make the somewhat tenuous but not implausible case that using sci-hub may lead to subscription cancellations which, in turn, may lead to scholarly societies (like those of Dr. McNutts employer, AAAS) to miss revenue they need in order to pay for important services (such as paying

In which a Science editorial demonstrates the ineffectiveness of OA activism

Over the years, publishers have left some astonishingly frank remarks over how they see their role in serving the scholarly community with their communication and dissemination needs. This morning, I decided to cherry-pick some of them, take them out of context to create a completely unrealistic caricature of publishers that couldn’t be further from the truth.

How do academic publishers see their role?

You’d be forgiven if after reading the title of this post, you thought scholars have started to revolt against journal rank. Unfortunately, while there is DORA and of course the evidence that journal rank is like homeopathy, most researchers are still fine with ex-scientists rejecting 92% of all submitted articles and charging a grand sum of more than US$30,000 per article that they select on a whim.

Publisher selects the best open access science – authors complain

Earning credibility in post-factual science?

This morning I was reminded of the age of some of the technology we’re using. Hyperlinks were developed at Stanford University and first demonstrated by their inventor Douglas Engelbart (using the first mouse) in 1968:  On Tuesday, Douglas Engelbart died, even before the scholarly literature was able to fully implement the technology he invented, 45 years and counting.

The dysfunctionality of the scholarly literature: hyperlinks

Scientists as social parasites?

Time and time again, academic publishers have managed to create the impression that publishing incurs a lot of costs which justify the outrageous prices they charge, be that US$11M p.a. for an

 Elsevier

Big Deal subscription or an article processing charge (APC) of US$5,200 for a

 Nature Communications

article.

How publishers keep fooling academics

I have now posted the job ads for the PostDoc position in our lab at

 Nature

,

 Science

, SfN and FENS.

PostDoc opportunity in our lab now advertized

As a regular user of the scholarly literature since before the internet (I started reading primary scientific literature for a high-school project around 1989), I have closely followed its digitization.

7 functionalities the scholarly literature should have

See this post with the associated press releases on brembs.net.

The

 F

orkhead B

 ox

P2 (FOXP2) gene is well-known for its involvement in language disorders. We have discovered that a relative of this gene in fruit flies,

 dFoxP

, is necessary for a type of learning called operant self-learning, which resembles some aspects of language learning.

The Drosophila FoxP gene is necessary for operant self-learning

Over the last ten years, scientific funding agencies across the globe have implemented policies which force their grant recipients to behave in a compliant way. For instance, the NIH OA policy mandates that research articles describing research they funded must be available via PubMedCentral within 12 months of publication. Other funders and also some institutions have implemented various policies with similar mandates.

Maybe try another kind of mandate?

The cost of knowledge – in 2003?

It’s the time of the year again where 30,000 neuroscientists head to the US to talk neuroscience. This year the big annual conference is in Washington, DC, one of the three cities able to host this large event. Our first poster will be up on Tuesday morning and shows results from operant self-stimulation experiments using optogenetics and dopaminergic neurons.

Heading for #SfN23 with two posters

There are regular discussions among academics as to who should be the prime mover in infrastructure reform. Some point to the publishers to finally change their business model. Others claim that researchers need to vote with their feet and change how they publish. Again others find that libraries should just stop subscribing to journals and use the saved money for a modern publishing system.

Who’s responsible for the lack of action?

Yesterday, cOAlition S published their updated principles and implementation guidelines for #PlanS, together with the rationale behind the update. This constitutes a very much welcome effort, as evidence of the increasing awareness among funders as to their potential leverage in infrastructure modernization, at a time when institutions have apparently abandoned their faculty completely.

Improved Plan S principles raise hope of more effective policies soon

The recent publication of the “Ten Principles of Plan S” has sparked numerous discussions among which one of several recurring themes was academic freedom. The cause for these discussions is the insistence of the funders supporting Plan S that their grant recipients only publish in certain venues under certain liberal licensing schemes.

Does academic freedom entail exemption from spending rules?

In his fantastic Peters Memorial Lecture on occasion of receiving CNI’s Paul Evan Peters award, Herbert Van de Sompel of Los Alamos National Laboratory described my calls to drop subscriptions as “radical” and “extremist” (starting at about minute 58):  Regardless of what Herbert called my views, this is a must-see presentation in which Herbert essentially presents the technology and standards behind the functionalities I have been asking for

Why academic journals need to go

“an academic career, in which a person is forced to produce scientific writings in great amounts, creates a danger of intellectual superficiality”

Albert Einstein Isaacson W (2008) Einstein (His Life and Universe) (Simon and Schuster, New York), 1st Ed, p 79

On the productivity of scientists

This is the tweetlog covering July 3-5: Interesting! We find something similar in flies: Live fast, die young: Long-lived mice are less active https://feedly.com/k/16RDz21 It smells fishy: Copper prevents fish from avoiding danger https://feedly.com/k/12gw14F @

 biocs

@

 google

Yes!

Tweetlog: neuroscience and #openaccess

In the last “Science Weekly” podcast from the Guardian, the topic was retractions.  At about 20:29 into the episode, Hannah Devlin asked, whether the reason ‘top’ journals retract more articles may be because of increased scrutiny there. The underlying assumption is very reasonable, as many more eyes see each paper in such journals and the motivation to shoot down such high-profile papers might also be higher.

Are more retractions due to more scrutiny?

Until today, I was quite proud of myself for not caving in to SIWOTI syndrome like Mike Taylor did. And then I read his post and caved in as well. What gets us so riled up is Elsevier’s latest in a long list of demonstration of what they think of the intellectual capacities of their customers. It’s precisely because it is only one in a long row that I initially didn’t feel like commenting.

Is this supposed to be the best Elsevier can muster?

For ages I have been planning to collect some of the main aspects I would like to see improved in an upgrade to the disaster we so euphemistically call an academic publishing system. In this post I’ll try to briefly sketch some of the main issues, from several different perspectives.

 As a reader:

I’d like to get a newspaper each morning that tells me about the latest developments, both in terms of general science news (aka.

What should a modern scientific infrastructure look like?

I really loathe reviewing for GlamMagz for two main reasons. For one, it’s hard to remain neutral: publication of a paper in my field in such a journal is beneficial both for the field and for the young people who are authors on this paper. Second, the demands of some of my colleagues so often make my blood boil. At that point I’m very happy these reviews are anonymous and I really don’t want to know the names of these colleagues.

Why this GlamMag will likely not ask for my review again

For our course this year I was planning a standard neurogenetic experiment. I hadn’t ever done this experiment in a course, yet, just two weeks ago I tried it once myself, with an N=1. The students would get two groups of

 Drosophila

fruit fly larvae, rovers and sitters (they wouldn’t know which was which). About ten larvae from each group would be placed on one of two yeast patches on an agar plate.

If only all science were this reproducible

Random Science Video: The value of fly research

Last week, Elizabeth Pennisi asked me to comment on the recent paper from Schreiweis

 et al.

entitled “Humanized FoxP2 accelerates learning by enhancing transitions from declarative to procedural performance”. Since I don’t know how much, if anything, of my answers to her questions will end up in her article, I thought I might expand my answer into a post about this very interesting work.

Humanized FoxP2 and the timing of habits

This is an easy calculation: for each subscription article, we pay on average US$5000. A publicly accessible article in one of SciELO’s 900 journals costs only US$90 on average. Subtracting about 35% in publisher profits, the remaining difference between legacy and SciELO costs amount to US$3160 per article.

Are we paying US$3000 per article just for paywalls?

The data clearly show that publications in

 Cell

,

 Nature

or

 Science

(

 CNS

for short), on average, cannot be distinguished from other publications, be it by methodology, reproducibility or other measures of quality. Even their citation advantage, while statistically significant, is so small that it is practically negligible.

No need to only send your best work to Science Magazine

There is an interesting study out in the journal PNAS: “Evaluating big deal journal bundles”. The study details the disparity in negotiation skills between different US institutions when haggling with publishers about subscription pricing.

Your university is definitely paying too much for journals

The other day I was alerted to an interesting evaluation of international citation data. The author, Curt Rice, mentions a particular aspect of the data:  The context here is that the “bottom” refers to scientific articles that aren’t cited, assuming that no citations mean low scientific quality of that article.

Citation inflation and incompetent scientists

Genetically Separable" href="https://www.slideshare.net/brembs/wcalb14" target="_blank"&gt;Pavlovian and Skinnerian Processes are Genetically Separable

Two evolutionary conserved, fundamental learning mechanisms

Sven Fund, CEO of the German publishing house de Gruyter was recently interviewed by Richard Poynder in his widely read interview series on open access. In the interview, he first avoided answering the question if de Gruyter had ever lobbied against open access.

Is de Gruyter’s lobby-by-proxy not lobbyism?

I just got the nicest decline to review ever:  That’s how you retire from science: you get to work like normal people. Awesome!

Retiring from science?

It is one of these rare events when I can post a video of one of my own talks. This one was in Berlin earlier this year, organized by The Lost Lectures in a very unusual venue, the Stattbad Wedding:  I’m planning to work more closely together with our computing center here to be able to record at least the lectures I give in English here at the university. So maybe there will be some more videos here, soon.

Video: Free will as an evolved brain function

Since the birth of our daughter, we spend our summers in Sweden, just like I used to, when I was little. This not only allows her to get more practice in Swedish then she gets talking with just me or her grandmother, but we also get to really recharge our batteries in the fabulous wilderness up there.

How to recharge in Sweden

A fistful of dollars: why corporate publishers have no place in scholarly communication

Following the example of Glyn Moody, I thought I’d start a log on the tweets I send around. One never knows what’ll happen to Twitter and besides, this provides a neat place to store and find everything. So here are the tweets for July first and second: Where are we, what still needs to be done?

Trying a new feature: Tweetlog

Flashback: All brains possess free will because there is no design in biology

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away.

Science, red in tooth and claw

*During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away. This post is from February 9, 2011: *     In this week’s journal club, we talked about an old paper from 1918!

Flashback: Nothing new in science?

During my flyfishing vacation last year, pretty much nothing was happening on this blog. Now that I’ve migrated the blog to WordPress, I can actually schedule posts to appear when in fact I’m not even at the computer. I’m using this functionality to re-blog a few posts from the archives during the month of august while I’m away. This post is from April 19, 2011:

Flashback: Creationists, this is the evidence you have to beat!

*As part of my scheduled re-posts during the summer break, I’ll also post some of the science videos from the archives. I originally posted this one on Agust 31, 2011: *

SummerScienceVideo: science is real

It might just save your life (via Upturned Microscope):    BTW, even if your life is not at stake, someone else’s may be. So you should publish your results if you are sure something definitely will not work, for instance in F1000 Research, where you can publish negative results for free until August 31, 2013. Your colleagues will be grateful.

One more reason to publish negative results

The recently released development draft for SHared Access Research Ecosystem (SHARE), authored by the Association of American Universities (AAU), the Association of Public and Land-grant Universities (APLU) and the Association of Research Libraries (ARL) in response to the OSTP memo on public access to federally funded research in the US sounds a lot like the library-based publishing system I’ve been perpetually arguing for.

SHARE: Library-based publishing becoming a reality?

Academic publishers have been parasitizing the public purse for long enough now. Steffen Böhm, director of the Essex Sustainability Institute, said it best: In his article, he mentions the successful SciELO project in South America. In a lot of ways, SciELO (scielo.org) is quite close to what I have been arguing for: SciELO means “Scientific Electronic

 Library

Online” and is supported by the Brazilian and Chilean government.

Cut out the parasitic middle men!

This year’s Winter Conference on Animal Learning and Behavior (WCALB) will be on one of my oldest and most central research projects, the commonalities and differences between operant and classical conditioning.

Almost 80 years on, progress on operant and classical conditioning

Amazing bead chain experiment

No matter how well-intended (and we all know to which place the road leads that is paved with good intentions!), transformative agreements (such as DEAL in Germany) are generally the wrong tool at the wrong time for making publicly funded science accessible to the public.

No Evilsevier DEAL!

The DFG is a very progressive and modern funding agency. More than two years ago, the main German science funding agency signed the “Declaration on Research Assessment” DORA.

German funder DFG: Why the sudden inconsistency?

tl;dr:
 
 It is a waste to spend more than the equivalent of US$100 in tax funds on a scholarly article.

Collectively, the world’s public purse currently spends the equivalent of US$~10b every year on scholarly journal publishing. Dividing that by the roughly two million articles published annually, you arrive at an average cost per scholarly journal article of about US$5,000.

How much should a scholarly article cost the taxpayer?

Today, our most recent paper got published, before traditional peer-review, at

 F1000 Research

. The research is about how nominally identical fly stocks can behave completely differently even if tested by the same person in the same lab in the same test.

The way academic publishing should be

UPDATE
 
 , 10-02-2015: After a hint from a user on Twitter, I now know that it is possible to open a PDF document in several windows, one for text, one for legends and one for figures. Figures and legends occupy one virtual desktop and the text another. In this way, I can actually review on-screen, but it is one heck of a work-around and by no means convenient.

I cannot take it any more.

Publishers, stop torturing your reviewers!

This is a slightly edited (amended, essentially) version of

my article published today at The Conversation. In cases where a problem within a community is detected and collective action is required to address the problem. one needs to strike a fine line or any efforts to convince the community that action is required will fail.

The Conversation: The looming crisis in science

You may have seen a neutered version of this post over at the LSE blog. This post below, however, puts the tiger in the tank, as it was enhanced by CatGPT:  Maybe scholarly societies have taken “the instruction“follow the money!” a tad too literally?

Scholarly societies: like a cat chasing the laser dot

The recent call for a GlamMag boycott by Nobel laureate Randy Shekman made a lot of headlines, but will likely have no effect whatsoever. For one, the call for boycott isn’t even close in scale to “the cost of knowledge” boycott against Elsevier and even that drew less than 15,000 measly signatures, a drop in the bucket with 970,000 board members, reviewers and authors working for Elsevier largely for free.

In support of subscripton cancellations

Currently, our libraries are paying about US$5000 per peer-reviewed subscription article. What is more difficult to find out is where all that money goes. Which steps are required to make an accepted manuscript public?

What goes into making a scientific manuscript public?

Talk about egg on face!

 Nature

“the world’s best science”

 Magazine

sets out to publish back-to-back papers on – of all topics – stem cell science.

Even the most thorough peer-review at the ‘best’ journals not up to snuff?

Public institutions the world over are required to spend their funds responsibly. Commonly, this is done by requiring them to host bids for purchases or services above a certain threshold. If you work at a public institution and have wondered, e.g., why you are only allowed to buy a computer from your computing facility which only sells one particular brand, then the answer likely is that this brand won the bidding contest.

Should public institutions not be choosing the lowest responsible bidder?

The recently discussed scenario of universal gold open access brought about by simply switching the subscriptions funds at libraries to have the libraries pay for author processing charges instead, seemed like a ghoulish nightmare. One of the few scenarios worse than the desolate state we call the

 status quo

today.

Whither now, Open Access?

Flashback: What can the spine teach us about learning?

Flashback: The neurobiology of operant conditioning

Our lab is looking for a PhD student interested in the molecular mechanisms of operant self-learning, a form of motor learning.

Looking for a PhD student

After Mike Taylor kept complaining about how horrible my old e107 platform was (which obviously it isn’t: I love this CMS), I finally gave in and moved everything over to a new home. The entire brembs.net domain with all its subdomains is no longer hosted in the good old US of A, where its home was since about 2000, when I moved there myself. After almost ten years back in Germany, I’ve now brought my online presence back home as well.

A new home for bjoern.brembs.blog

I recently was sent a report from a university-wide working group on the publishing habits within the Freie Universität Berlin. I don’t think this document is available online, but I think I’m not doing anything illegal if I publish some of the survey results here. The working group polled all faculty members of the university on various questions concerning scholarly publishing.

How important is the Impact Factor?

Think, check, submit: who hasn’t heard of this mantra to help researchers navigate the jungle of commercial publishers? Who isn’t under obligation to publish in certain venues, be it because employers ask for a particular set of journals for hiring, tenure or promotion, or because of funders’ open access mandates?

How academic institutions neglect their duty

The academic journal publishing system sure feels all too often a bit like a sinking boat: we have a reproducibility leak an affordability leak a functionality leak a data leak a code leak an interoperability leak a discoverability leak a peer-review leak a long-term preservation leak a link rot leak an evaluation/assessment leak a data visualization leak … … … and even a tiny access leak still remains even after 30 years of trying to fix it.

Scholarly publishing in three cartoons

bjoern.brembs.blog

I just sent the poster for this year's Society for Neuroscience meeting
to the printer. As our graduate student is preparing his defense and our
postdoc did not get a visa (no thanks, US!), we just have a single
poster this year and I will present it myself on Monday, November 14,
2022, 8:00 AM -- 12:00 PM, on poster board WW53.

Contrary to our plans, this poster will not just contain the work of
postdoc Dr. Radostina Lyutova, but also some PhD thesis results from
graduate student Andreas Ehweiner. The general topic is how animals
learn from the consequences of their actions. To this end, we train
*Drosophila* fruit flies in different situations, with or without
genetically manipulated nervous system. In the first situation, the
tethered animals control a punishing heat beam with their yaw torque
(roughly corresponding to turning attempts around the vertical body
axis). In such experiments, wild type animals form a motor memory after
8 minutes of training. We have called the type of learning giving rise
to this memory self-learning, because the animals are exclusively
learning about their own behavior. This is in contrast to a second, very
similar experiment, where we have made one seemingly small, but highly
consequential modification. In this 'composite' situation, the animal is
controlling the heat as before, but now the environment of the fly is
colored in either green or blue, depending on the attempted turning
direction. In other words, now the animal can not only form a motor
memory about the un/punished turning directions, it can also learn which
color is associated with heat. We call this form of learning
world-learning, because the animal is learning about relationships in
the world around it.

More then ten years ago now, we developed tests to probe which learning
mechanism is engaged under which circumstances.

For instance, both after yaw torque training (where the self-learning
mechanism is engaged) and after composite training, we test for torque
preference (i.e., whether a motor memory has been formed) without
colors. After eight minutes of torque training, wild type flies show
motor memory, while after eight minutes of composite training, no such
motor memory can be detected. We are hypothesizing that the
world-learning mechanism is engaged in composite training and inhibits
the self-learning mechanism. Without colors, the self-learning mechanism
is free to operate, so motor memory is formed during torque training.

On the poster, we now show the most recent results on the molecular
components of the self-learning mechanism and how the world-learning
mechanism inhibits self-learning. We found that the gene for the
atypical protein kinase C (aPKC) is necessary for self-learning and that
it likely acts in motor neurons that also express the *FoxP* gene. When
we overexpress a constitutively active form of aPKC, this improves
self-learning so much, that such flies not only can form a motor memory
after 4 minutes of training (not sufficient for learning in wild type
flies), but also can overcome the inhibition of motor learning by the
world-learning mechanism, such that motor memory is detectable after
eight minutes of composite training. Because we knew that this
inhibition acts via neurons in the neuropil called the mushroom body, we
also screened mushroom body output neurons (MBONs) to find out where the
inhibition is transmitted from the mushroom bodies. We silenced these
MBONs one category at a time, looking for lines which showed motor
memory, similar to the flies with the improved self-learning. we found
three candidate lines and the rescreen of these lines is still in
progress.

The poster can be downloaded by clicking on the picture below:

<figure class="wp-block-image size-full is-resized">
<a href="bjoern.brembs.net/download/sfn_2022/?wpdmdl=2486"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2022/11/sfn22-2.png"
class="wp-image-2493" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2022/11/sfn22-2.png 1000w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/11/sfn22-2-300x177.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/11/sfn22-2-768x452.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/11/sfn22-2-50x29.png 50w"
sizes="(max-width: 750px) 100vw, 750px" width="750" height="442"
alt="Poaster" /></a>
</figure>

I just sent the poster for this year’s Society for Neuroscience meeting to the printer. As our graduate student is preparing his defense and our postdoc did not get a visa (no thanks, US!), we just have a single poster this year and I will present it myself on Monday, November 14, 2022, 8:00 AM – 12:00 PM, on poster board WW53.

Interacting learning systems at SfN22

The first conference after the Sars CoV2 pandemic! We're headed for
Paris, France tomorrow and our lab will present two posters, the work of
graduate student Andreas Ehweiner and postdoc Radostina Lyutova.

Andreas has been working on the cellular and genetic mechanisms
underlying operant self-learning (a form of motor learning). On his
poster, he presents evidence that one crucial site of plasticity for
this type of motor learning is motor neurons of the fly ventral nerve
cord co-expressing both *FoxP* and *aPKC*. Interestingly, *FoxP*
expression in the brain seems to be dispensable for self-learning and
knocking-out *FoxP* in all neurons in the adult only seems to show an
effect on learning 14 days after the knock-out. Overexpressing a
constitutively active form of *aPKC* improves motor learning, such that
these flies still learn when training has been reduced to a level where
wild-type flies no longer show a significant learning score. I'm
particularly happy that we now seem to have found which of the five
*Drosophila* PKC genes is involved in operant self-learning. We had been
trying to identify the right PKC for a few years now. Surprisingly, it
is not the same PKC as the one that is required for self-learning in
*Aplysia*, for instance. Andreas is writing up his thesis at the moment,
so he sure would appreciate job offers. Andreas is smart, resourceful
and persistent. Here is his poster (link opens A0 PDF):

<figure class="wp-block-image size-large">
<a href="https://bjoern.brembs.net/wp/?wpdmdl=2448"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1024x684.png"
class="wp-image-2455" loading="lazy" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1024x684.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-300x200.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-768x513.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1536x1026.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-2048x1368.png 2048w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-50x33.png 50w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024"
height="684" /></a>
</figure>

Radostina studies the regulation of self-learning by other forms of
learning. Operant self-learning only requires eight minutes of training
(see Andreas' poster) when no other stimuli can be learned. If such
stimuli are present, self-learning requires overtraining of 16 minutes.
This procedure is reminiscent of habit formation in vertebrates.
Radostina found that habit formation in flies is regulated by a single
cell receiving input from a prominent insect neuropil, the mushroom
body. If she inhibits this cell, flies show a habit already after eight
minutes, suggesting that the inhibition of self-learning is mediated via
this mushroom body output neuron (MBON 02). Connectome analysis revealed
that MBON 02 input is provided mainly by Kenyon cells from the
little-studied lateral and dorsal accessory calyx, which, in turn,
receive thermosensory and visual input, respectively. This has been a
massive effort over several years, clouded by a case of sabotage, that
Radostina has picked up and breathed new life into. Here is her poster:

<figure class="wp-block-image size-large">
<a href="https://bjoern.brembs.net/wp/?wpdmdl=2446"><img
src="https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-1024x724.png"
class="wp-image-2456" loading="lazy" decoding="async"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-1024x724.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-300x212.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-768x543.png 768w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-1536x1085.png 1536w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-2048x1447.png 2048w, https://bjoern.brembs.net/wp/wp-content/uploads/2022/07/image-1-50x35.png 50w"
sizes="(max-width: 1024px) 100vw, 1024px" width="1024"
height="724" /></a>
</figure>

The first conference after the Sars CoV2 pandemic! We’re headed for Paris, France tomorrow and our lab will present two posters, the work of graduate student Andreas Ehweiner and postdoc Radostina Lyutova.

Off to Paris for #FENS2022 with two posters

Last week, [Elizabeth
Pennisi](https://news.sciencemag.org/author/elizabeth-pennisi) asked me
to comment on the [recent paper from Schreiweis *et
al.*](https://www.pnas.org/cgi/doi/10.1073/pnas.1414542111) entitled
"Humanized FoxP2 accelerates learning by enhancing transitions from
declarative to procedural performance". Since I don't know how much, if
anything, of my answers to her questions will end up in [her
article](https://news.sciencemag.org/biology/2014/09/human-speech-gene-can-speed-learning-mice),
I thought I might expand my answer into a post about this very
interesting work.

As the title implies, Schreiweis *et al.* have tested transgenic mice in
which the mouse version of the [language-related gene
FoxP2](https://en.wikipedia.org/wiki/FOXP2) was replaced with the human
version. They found that the timing of when repeated behaviors become
stereotypic is altered, such that the behaviors become stereotypic
earlier in the humanized mice than in the unaltered animals.

Importantly, this was only observed in tasks where two learning systems
were engaged simultaneously. In the literature, there are several
accounts of how to label these learning systems. In vertebrate learning
they are often referred to as procedural vs. declarative (also in
Schreiweis *et al*.), in animal navigation many authors refer to them by
allocentric vs. egocentric, and in *Drosophila* fruit flies we have
coined the terms world- vs. self-learning. The gist behind these word
pairs is that brains as different as those from insects and mammals seem
to adhere to a common functional organization that makes a very
fundamental distinction between self and non-self on various levels. Of
relevance to the current research is that external cues are treated by
different brain regions and learning of relationships among external
cues is mediated by different molecular processes than the internal
processes controlling behavior. Hence our distinction between [world-
and self-learning](http://blogarchive.brembs.net/comment-n794.html).

In situations where both world- and self-learning can occur
simultaneously, world-learning commonly dominates in the first phases of
training, while self-learning kicks in later. There is converging
evidence from vertebrates and invertebrates suggesting that this
staggering is probably accomplished by inhibitory connections from
circuits engaged in world-learning slowing down the circuits involved in
self-learning. Thus, it is this negotiation between self- and
world-learning which provides us with time to practice our skills before
they become automatic. One may also say that this negotiation is the
reason why it takes time (and how much time it takes) to form habits.
I've written a [longer
account](http://blogarchive.brembs.net/comment-n802.html) of this
negotiation on occasion of the poster publication of some of the
Schreiweis *et al.* work in 2011.

The recently published work by Schreiweis *et al*.  now contains both
molecular genetic and physiological results in addition to the
behavioral data. It adds weight to the so-called 'motor-learning
hypothesis' that came up some time around 2006/7 or thereabout. This
hypothesis posits that FoxP2 is mainly involved in the motor, or speech
component of language, i.e., learning to control the muscles in the
lips, tongue, voice chords, etc. in order to articulate syllables and
words.The movements of these organs have to become stereotypic in order
to reliably produce understandable language and the main experimental
paradigms for this stereotypization of behavior (independent of
language) have been procedural learning and habit formation. This work
provides further evidence that indeed FoxP2 is an important component of
the learning process that leads to automatic, stereotypic behavior.

In particular, it suggests that FoxP2 is involved in the control of the
process of stereotypization, i.e., at what point the behavior shifts
from being flexible, to becoming more rigid. Until this work, the
evidence from vertebrates and invertebrates has pointed to FoxP genes to
be involved in the automatization of behavior. Now, this evidence is
extended to also -- at least in mammals -- include the negotiation
process, which I don't think anybody had on the radar thus far.

One of the most interesting mechanistic questions that derive from the
fact that these mice only showed an effect on the negotiation between
the two learning systems (and not on the individual systems when
isolated), is how this negotiation takes place. Again, converging
evidence from invertebrates and vertebrates points towards inhibitory
connections from the world-learning processes keeping a break on the
self-learning processes. Is FoxP directly affecting these inhibitory
connections, or is it just subtly increasing the relative strength of
the procedural/self mechanism, such that it cannot be detected in
individual experiments where the components have been isolated, but only
in experiments where the negotiation actually takes place? The
physiological results by Schreiweis et al. point towards the latter:
induction of [long term
depression](https://en.wikipedia.org/wiki/Long-term_depression) (LTD) in
the dorsolateral, but not the dorsomedial striatum is enhanced in the
humanized mice -- and the dorsolateral striatum is the region thought to
be involved in self-learning, while some world-learning processes have
been localized to the dorsomedial striatum.

::: {#attachment_648 .wp-caption .aligncenter style="width: 530px"}
[![The mice with the humanized version of FoxP2 form habits earlier and
this might be due to earlier formation of LTD in the dorsomedial
striatum.](https://bjoern.brembs.net/wp/wp-content/uploads/2014/09/humfoxp-1024x339.png){.size-large
.wp-image-648 fetchpriority="high" decoding="async"
aria-describedby="caption-attachment-648" width="520" height="172"
srcset="https://bjoern.brembs.net/wp/wp-content/uploads/2014/09/humfoxp-1024x339.png 1024w, https://bjoern.brembs.net/wp/wp-content/uploads/2014/09/humfoxp-300x99.png 300w, https://bjoern.brembs.net/wp/wp-content/uploads/2014/09/humfoxp.png 1805w"
sizes="(max-width: 520px) 100vw, 520px"}](https://bjoern.brembs.net/wp/wp-content/uploads/2014/09/humfoxp.png)

Mice with the humanized version of FoxP2 form habits earlier and this
might be due to earlier formation of LTD in the dorsolateral striatum.
(Fig. S7 in Schreiweis *et al*.)
:::

The generation of these humanized mice was a particularly cool aspect of
the work. Compared to other, more common transgenic manipulations (e.g.
knock-outs), this humanization of FoxP2 is a rather sophisticated and
subtle alteration with rather nuanced but nevertheless very exciting
consequences. Many of the more drastic FoxP manipulations are homozygous
lethal and since there is evidence for positive selection of the human
variant, it was very straightforward to try and see what the human
variant would do in an organism that doesn't normally express this
version. Moreover, such a subtle alteration may uncover more subtle
roles of FoxP than the cruder manipulations have been able to. In fact,
the most specific behavioral consequences of any gene manipulation have
commonly been the most subtle of genetic manipulations. Therefore, the
scientific value of this manipulation extends far beyond the fact that
it mimics the human gene.

One needs to keep in mind, though, that it was only the structure of the
protein that was humanized, the regulatory region of the gene was not
altered, i.e., the putative expression pattern of the humanized FoxP2
gene is still that of the mouse version (and I don't know how different
the human regulatory region is from the mouse one -- in fact, I'm not
sure if we have full knowledge about the regulatory region of FoxP2,
yet).

Thus, it is quite amazing that these mice showed any difference at all
to WT mice, subtle as these differences may be perceived to be.

On a wider perspective, this work adds to our growing understanding of
the relation between learning and language acquisition. Schreiweis *et
al*.'s results fall very nicely within a string of recent work
suggesting that a major component of language acquisition is based on a
form of learning called [operant
conditioning](http://blogarchive.brembs.net/comment-n734.html). The
debate about the relevance of this form of learning for language is at
the core of the idea history of neuroscience and psychology. In 1957, BF
Skinner published "[Verbal
Behavior](https://en.wikipedia.org/wiki/Verbal_Behavior)" in which he
made the sweeping claim that language was essentially acquired via
operant learning.

Two years later, Noam Chomsky took Skinner to task in what would become
one of the cornerstones in the fall of behaviorism and the rise of
cognitive neuroscience and with it, of course, Chomsky's rise to fame as
one of the US' leading intellectuals.

If one can summarize Chomsky's massive (32 pages) [book
review](https://www.chomsky.info/articles/1967----.htm) in a single
sentence, it might be: "it may look like operant learning, but you don't
have any evidence". Instead, Chomsky went on to famously propose that we
all have inborn language acquisition devices as well as 'universal
grammar'. Of course, Chomsky also did not provide any evidence,
either.In the absence of any evidence on either side, Chomsky's
outstanding rhetorical skills prevailed and changed nearly all of
psychology and neuroscience for the coming 5 decades until this day (I'm
simplifying and exaggerating somewhat, for the sake of brevity and
argument).

In the last few years, evidence has accumulated not only that the
concept of universal grammar likely is untenable, but also that indeed
operant learning (and especially the form of operant learning called
motor learning) is an important if not crucial component of language
acquisition, in particular the speech component of language. For
instance, [*FoxP* manipulations in
flies](https://bjoern.brembs.net/2014/06/the-drosophila-foxp-gene-is-necessary-for-operant-self-learning/)
specifically affect operant self-learning, but not other forms of
learning. Thus, the currently available evidence points towards an
ancestral FoxP function in self-learning, a function that is not only
conserved in humans, but one that has been further honed by evolution to
allow for the acquisition of language.This work by Schreiweis *et al*.
falls neatly within this last string of publications tilting the outcome
of this long-standing debate more and more in Skinner's favor.

As we don't know the exact mechanism by which the negotiation between
self- and world-learning processes takes place, one can only speculate
what advantage the current human version of the FoxP2 gene might have
conferred. One interesting aspect here might be that it may have been
critical for the evolution of language to speed up the stereotypization
of certain orofacial movements during the first attempts to articulate.

A further, even more tentative speculation might be that this speeding
up was adaptive, because it allowed more effective communication between
parents and their infants, at an earlier time point in the development
of the child, when it was beneficial for the vulnerable infant to convey
its status in a more nuanced way than just crying to its caregivers. In
this way, children which were able to speak earlier may have had a
survival advantage over those that spoke later.But then again, at this
time point, such speculations are merely just so stories.

On a personal note, being so used to data mostly falsifying my
hypotheses over the last 20 years, it makes me quite nervous that now in
this particular research field, everything seems to fit so well
together. If something fits so well to one's ideas, one should be
especially cautious and (beware of confirmation bias!), think hard to
make doubly sure that the next experiments are designed such that they
can easily yield results that contradict the current hypothesis, more so
than usual.

And on a side note, it is quite an irony that [three years
ago](https://bjoern.brembs.net/2014/06/why-use-fruit-flies-to-study-a-gene-involved-in-language/)
a reviewer (for the same journal that now published his work, PNAS)
heavily criticized our essentially analogous conclusions. Now, three
years later, PNAS is finally ready to publish work that supports the
motor hypothesis.

------------------------------------------------------------------------

[Schreiweis, C., Bornschein, U., Burguiere, E., Kerimoglu, C.,
Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C., Puliyadi,
R., Groszer, M., Fisher, S., Mundry, R., Winter, C., Hevers, W., Paabo,
S., Enard, W., & Graybiel, A. (2014). Humanized Foxp2 accelerates
learning by enhancing transitions from declarative to procedural
performance [Proceedings of the National Academy of
Sciences]{style="font-style: italic;"} DOI:
[10.1073/pnas.1414542111](https://dx.doi.org/10.1073/pnas.1414542111){rev="review"}]{.Z3988
title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences&rft_id=info%3Adoi%2F10.1073%2Fpnas.1414542111&rfr_id=info%3Asid%2Fresearchblogging.org&rft.atitle=Humanized+Foxp2+accelerates+learning+by+enhancing+transitions+from+declarative+to+procedural+performance&rft.issn=0027-8424&rft.date=2014&rft.volume=&rft.issue=&rft.spage=&rft.epage=&rft.artnum=http%3A%2F%2Fwww.pnas.org%2Fcgi%2Fdoi%2F10.1073%2Fpnas.1414542111&rft.au=Schreiweis%2C+C.&rft.au=Bornschein%2C+U.&rft.au=Burguiere%2C+E.&rft.au=Kerimoglu%2C+C.&rft.au=Schreiter%2C+S.&rft.au=Dannemann%2C+M.&rft.au=Goyal%2C+S.&rft.au=Rea%2C+E.&rft.au=French%2C+C.&rft.au=Puliyadi%2C+R.&rft.au=Groszer%2C+M.&rft.au=Fisher%2C+S.&rft.au=Mundry%2C+R.&rft.au=Winter%2C+C.&rft.au=Hevers%2C+W.&rft.au=Paabo%2C+S.&rft.au=Enard%2C+W.&rft.au=Graybiel%2C+A.&rfe_dat=bpr3.included=1;bpr3.tags=Medicine%2CPsychology%2CNeuroscience%2CCancer%2C+Hematology%2C+Behavioral+Neuroscience%2C+Neurolinguistics%2C+Comparative+Psychology%2C+Evolutionary+Psychology%2C+Language%2C+Learning"}
