With everyone in a reflective mood as the year comes to a close, one of the big scientific trends of 2012 has obviously been the high profile that open-access and more open methods of carrying out science has received.

Regular reader of this blog will be aware of our efforts to promote data citation using digital object identifiers (DOIs), and this week, alongside Rebecca Lawrence from F1000 Research and Kevin Ashley from the Digital Curation Centre, our Editor in Chief Laurie Goodman has a correspondence in Nature strongly making this case.

With advances in sequencing technologies leading to a so-called “data deluge”, the amount of data supporting a biological study is becoming increasingly unwieldy and difficult to make available. These issues have led to a lack of transparency in analyses of sequencing data, resulting in an ever-increasing reproducibility gap.

New research in GigaScience on the genome of the Wuzhishan minipig The availability of a high quality reference genome sequence for a species is extremely important in the deeper understanding of its biology, evolution, and comparative genomics.

The worm that turned (epigenetics) GigaDB, GigaScience ’s associated database, has had a number of new datasets just added, many for data types previously not hosted. Today marks the publication of new research in our sister BMC journal Genome Biology shaking up the epigenetics field by shattering the assumption that DNA methylation is absent in nematodes.

A Grassroots Funding effort in Puerto Rico enables genome sequencing of the critically endangered Puerto Rican parrot The rationale and scope for GigaScience has been to cover and provide a home for the growing number of studies producing and handling large-scale biological data, and this “big-data” data bonanza is not just due to well funded labs, but an increasingly globalized and distributed network of researchers.

In the midst of a busy few weeks of European meetings, GigaScience is currently in Basel, where ECCB 2012 (the European Conference of Computational Biology) has just ended. Usually overshadowed by its bigger sibling: the ISMB (particularly when both meetings are in Europe and co-hosted), this was the first time that I had attended the stand-alone meeting and it more than justified being a stand-alone event.

As we enter a new month, we have to announce some personnel changes to GigaScience , as we welcome Nicole Nogoy to the team as a Commissioning Editor from her base in New Zealand. It is with sadness we also have to say goodbye to our Assistant Editor Alexandra Basford, who has just left us to take up new challenges in Japan.

The precipitous drop in the price of next generation sequencing coupled with its increasing sensitivity has opened up whole new areas of research, one of the most interesting in recent years being the advent of single-cell sequencing. Combining advances in flow-sorting of cells, whole genome amplification and the latest sequencing technologies is now allowing researchers to study tumor evolution on a single-cell level.

Scientific workflow software such as Taverna, Knime and Pipeline Pilot can overcome interoperability issues relating to the access of tools and data format conversions. Such tasks are automatically handled by the data processing pipeline during its enactment by the workflow software. Galaxy is another workflow system, and its annual conference was held last month at the University of Chicago.

Type any scientific term into any search engine and its pretty much guaranteed that a Wikipedia article will be the first hit.