(Previously: 2022) #1. Tony Fadell, Build #2. Giff Constable, Talking To Humans #3. Ben Horowitz, The Hard Thing About Doing Hard Things #4. Dale Carnegie, How To Win Friends And Influence People Sounds Machiavellian, but actually quite wholesome: a “dad book,” as my friend

“And I took the little scroll from the hand of the angel and ate it.

I took a pistol course in undergrad, and while I was a poor marksman I enjoyed the experience.

“Like arrows in the hand of a warrior are the children of one's youth.” –Psalm 127:4

Quantum computing gets a lot of attention these days. In this post, I want to examine the application of quantum computing to quantum chemistry, with a focus on determining whether there are any business-viable applications today.

In 2019, ChemistryWorld published a “wish list” of reactions for organic chemistry, describing five hypothetical reactions which were particularly desirable for medicinal chemistry.

(in the spirit of Dale Carnegie and post-rat etiquette guides)

“A cord of three strands is not easily broken.” —Ecclesiastes 4:12

ICYMI: Ari and I announced our new company, Rowan! We wrote an article about what we're hoping to build, which you can read here. Also, this blog is now listed on The Rogue Scholar, meaning that posts have DOIs and can be easily cited.

The Pauling model for enzymatic catalysis states that enzymes are “antibodies for the transition state”—in other words, they preferentially bind to the transition state of a given reaction, rather than the reactants or products.

Since the ostensible purpose of organic methodology is to develop reactions that are useful in the real world, the utility of a method is in large part dictated by the accessibility of the starting materials.