Rogue Scholar

Published April 9, 2011 in Henry Rzepa's Blog

Understanding why and how proteins fold continues to be a grand challenge in science. I have described how Wrinch in 1936 made a bold proposal for the mechanism, which however flew in the face of much of then known chemistry.

References

General ChemistryCatalysis

Pauling's Left-Handed α-Helix

https://doi.org/10.1002/1521-3773(20011119)40:22<4167::aid-anie4167>3.0.co;2-q

Published November 16, 2001 in Angewandte Chemie International Edition

Author Jack D. Dunitz

Physical and Theoretical ChemistryComputer Science Applications

Assessment of the Performance of DFT and DFT-D Methods for Describing Distance Dependence of Hydrogen-Bonded Interactions

https://doi.org/10.1021/ct100469b

Published December 2, 2010 in Journal of Chemical Theory and Computation

Authors Kanchana S. Thanthiriwatte, Edward G. Hohenstein, Lori A. Burns, C. David Sherrill

Colloid and Surface ChemistryBiochemistryGeneral ChemistryCatalysis

Heterogeneity and Stability of Helical Conformations in Peptides: Crystallographic and NMR Studies of a Model Heptapeptide

https://doi.org/10.1021/ja960665u

Published January 1, 1996 in Journal of the American Chemical Society

Authors Arindam Banerjee, S. Datta, Animesh Pramanik, N. Shamala, P. Balaram

Multidisciplinary

Determination of the Absolute Configuration of Optically Active Compounds by Means of X-Rays

https://doi.org/10.1038/168271a0

Published August 1, 1951 in Nature

Authors J. M. BIJVOET, A. F. PEERDEMAN, A. J. van BOMMEL

Multidisciplinary

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain

https://doi.org/10.1073/pnas.37.4.205

Published April 1, 1951 in Proceedings of the National Academy of Sciences

Authors Linus Pauling, Robert B. Corey, H. R. Branson

Why are α-helices in proteins mostly right handed?