Published in Henry Rzepa's Blog
Author Henry Rzepa
tpap[cite]10.1055%2Fs-1994-25538[/cite], as it is affectionately known, is a ruthenium-based oxidant of primary alcohols to aldehydes discovered by Griffith and Ley.
References
Organic Chemistry
Autocatalysis during the reduction of tetra-n-propylammonium perruthenate by 2-propanol
Published in The Journal of Organic Chemistry
Authors Donald G. Lee, Zhao Wang, W. David Chandler
Successful Computational Modeling of Isobornyl Chloride Ion-Pair Mechanisms
Published in The Journal of Organic Chemistry
Authors Jing Kong, Paul v. R. Schleyer, Henry S. Rzepa
Organic ChemistryCatalysis
Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis
Published in Synthesis
Authors Steven V. Ley, Joanne Norman, William P. Griffith, Stephen P. Marsden
Organic ChemistryGeneral ChemistryCatalysis
The oxidation of cyclobutanol by ruthenium tetroxide and sodium ruthenate
Published in Canadian Journal of Chemistry
Authors Donald G. Lee, Udo A. Spitzer, James Cleland, Merle E. Olson
The only detectable product obtained from the oxidation of cyclobutanol by ruthenium tetroxide or sodium ruthenate is cyclobutanone. This indicates that both of these reagents act as two-electron transfer oxidants and that the oxidation of alcohols by ruthenium tetroxide likely proceeds via a mechanism that involves a pair of successive two-electron transfer steps.