References

General ChemistryCatalysis

Disappearing Polymorphs Revisited

Published in Angewandte Chemie International Edition
Authors Dejan‐Krešimir Bučar, Robert W. Lancaster, Joel Bernstein

AbstractNearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of polymorphs that disappear. The inability to obtain a crystal form that has previously been prepared is indeed a frustrating and potentially serious problem for solid‐state scientists. This Review discusses recent occurrences and examples of disappearing polymorphs (as well as the emergence of elusive crystal forms) to demonstrate the enduring relevance of this troublesome, but always captivating, phenomenon in solid‐state research. A number of these instances have been central issues in patent litigations. This Review, therefore, also highlights the complex relationship between crystal chemistry and the law.

Organic ChemistryPhysical and Theoretical Chemistry

Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development

Published in Organic Process Research & Development
Authors Sanjay R. Chemburkar, John Bauer, Kris Deming, Harry Spiwek, Ketan Patel, John Morris, Rodger Henry, Stephen Spanton, Walter Dziki, William Porter, John Quick, Phil Bauer, John Donaubauer, B. A. Narayanan, Mauro Soldani, Dave Riley, Kathyrn McFarland